Article
Voltage-gated sodium channel polymorphisms play a pivotal role in the development of oxaliplatin-induced peripheral neurotoxicity: results from a prospective multicenter study.
Cancer - 1 Oct 2013
Argyriou Andreas A, Cavaletti Guido, Antonacopoulou Anna, Genazzani Armando A, Briani Chiara, Bruna Jordi, Terrazzino Salvatore, Velasco Roser, Alberti Paola, Campagnolo Marta, Lonardi Sara, Cortinovis Diego, Cazzaniga Marina, Santos Cristina, Psaromyalou Aikaterini, Angelopoulou Aikaterini, Kalofonos Haralabos P
Abstract excerpt
BACKGROUND: The current prospective, multicenter study sought to identify single nucleotide polymorphisms of voltage-gated sodium channels (SCNAs) genes that might confer susceptibility to an increased incidence and severity of oxaliplatin-induced peripheral neuropathy (OXAIPN) in patients treated with either leucovorin, 5-fluorouracil, and oxaliplatin (FOLFOX) or oxaliplatin plus capecitabine (XELOX) for...
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