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Article

Polymorphism of CAG motif of SK3 gene is associated with acute oxaliplatin neurotoxicity.

Cancer chemotherapy and pharmacology - 1 May 2011

Basso Michele, Modoni Anna, Spada Daniele, Cassano Alessandra, Schinzari Giovanni, Lo Monaco Mauro, Quaranta Davide, Tonali Pietro Attilio, Barone Carlo

Abstract excerpt

PURPOSE: There is no agreement on which channel is involved in oxaliplatin neurotoxicity, most investigators favouring voltage-gated sodium channels. However, the small conductance Ca(++) activated K(+) channels, encoded by the SK1-3 genes, are also involved in membrane excitability, playing a role in after-hyperpolarization at the motor nerve terminal. As the SK3 gene is characterized in Caucasians by a highly...

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PMID: 20872144
DOI: 10.1007/s00280-010-1466-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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