Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic determinants of chronic oxaliplatin-induced peripheral neurotoxicity: a genome-wide study replication and meta-analysis.

Journal of the peripheral nervous system : JPNS - 1 Mar 2015

Terrazzino Salvatore, Argyriou Andreas A, Cargnin Sarah, Antonacopoulou Anna G, Briani Chiara, Bruna Jordi, Velasco Roser, Alberti Paola, Campagnolo Marta, Lonardi Sara, Cortinovis Diego, Cazzaniga Marina, Santos Cristina, Kalofonos Haralabos P, Canonico Pier Luigi, Genazzani Armando A, Cavaletti Guido

Abstract excerpt

We aimed at validating the role of genetic variants identified by a recent genome-wide association study (GWAS) as determinants of chronic oxaliplatin-induced peripheral neurotoxicity (OXAIPN). Eight polymorphisms (rs10486003, rs2338, rs843748, rs797519, rs4936453, , , and ) were genotyped in a total of 150 colorectal cancer patients of Caucasian origin receiving oxaliplatin-based...

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acid Anhydride Hydrolases
Share to Aged, 80 and over
Share to Antineoplastic Agents
Share to Colorectal Neoplasms
Share to Genome-Wide Association Study
Share to Organoplatinum Compounds
Share to Oxaliplatin
Share to Peripheral Nervous System Diseases

Source

Identifiers

PMID: 25858589
DOI: 10.1111/jns.12110

Genes

ACYP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic determinants of chronic oxaliplatin-induced peripheral neurotoxicity: a genome-wide study replication and meta-analysis.PMID 25858589Read ↗

Genetic polymorphisms associated with oxaliplatin-induced peripheral neurotoxicity in Japanese patients with colorectal cancer.Semantic proximity Read ↗

Voltage-gated sodium channel polymorphisms play a pivotal role in the development of oxaliplatin-induced peripheral neurotoxicity: results from a prospective multicenter study.Semantic proximity Read ↗

Pharmacogenetic predictors of severe peripheral neuropathy in colon cancer patients treated with oxaliplatin-based adjuvant chemotherapy: a GEMCAD group study.Semantic proximity Read ↗

Updates on Oxaliplatin-Induced Peripheral Neurotoxicity (OXAIPN)Semantic proximity Read ↗

Genetic polymorphisms in cyclin H gene are associated with oxaliplatin-induced acute peripheral neuropathy in South Indian digestive tract cancer patients.Semantic proximity Read ↗

Polymorphic markers associated with severe oxaliplatin-induced, chronic peripheral neuropathy in colon cancer patients.Semantic proximity Read ↗

Associations between oxaliplatin-induced peripheral neuropathy and polymorphisms of the ERCC1 and GSTP1 genesSemantic proximity Read ↗

Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development.Semantic proximity Read ↗

Large-scale prospective pharmacogenomics study of oxaliplatin-induced neuropathy in colon cancer patients enrolled in the JFMC41-1001-C2 (JOIN Trial).Semantic proximity Read ↗

Oxaliplatin-Induced Neuropathy: Genetic and Epigenetic Profile to Better Understand How to Ameliorate This Side EffectSemantic proximity Read ↗

Development and Validation of the Chemotherapy-induced Peripheral Neuropathy Integrated Assessment – Oxaliplatin Subscale: A Prospective Cohort StudySemantic proximity Read ↗

Integrin beta‐3 L33P: a new insight into the pathogenesis of chronic oxaliplatin‐induced peripheral neuropathy?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.