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Article

Associations between oxaliplatin-induced peripheral neuropathy and polymorphisms of the ERCC1 and GSTP1 genes

1 Nov 2010

Abstract excerpt

OBJECTIVE: Oxaliplatin-induced chronic neuropathy is cumulative and dose-limiting; reliable predictors and determination of the mechanism of this toxic effect are needed. METHODS: We retrospectively studied 51 Japanese adults with colorectal cancer who had received oxaliplatin-based chemotherapy to explore the pharmacogenetic association between oxaliplatin-induced neuropathy and polymorphisms of the excision...

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Share to Cancer Treatment and Pharmacology
Share to Chemotherapy-induced organ toxicity mitigation
Share to Colorectal Cancer Treatments and Studies

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PMID: 20979931
DOI: 10.5414/cpp48729

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Associations between oxaliplatin-induced peripheral neuropathy and polymorphisms of the ERCC1 and GSTP1 genesPMID 20979931Read ↗

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