Article
Pathway analysis of genome-wide data improves warfarin dose prediction.
BMC genomics - 1 Jan 2013
Daneshjou Roxana, Tatonetti Nicholas P, Karczewski Konrad J, Sagreiya Hersh, Bourgeois Stephane, Drozda Katarzyna, Burmester James K, Tsunoda Tatsuhiko, Nakamura Yusuke, Kubo Michiaki, Tector Matthew, Limdi Nita A, Cavallari Larisa H, Perera Minoli, Johnson Julie A, Klein Teri E, Altman Russ B
Abstract excerpt
BACKGROUND: Many genome-wide association studies focus on associating single loci with target phenotypes. However, in the setting of rare variation, accumulating sufficient samples to assess these associations can be difficult. Moreover, multiple variations in a gene or a set of genes within a pathway may all contribute to the phenotype, suggesting that the aggregation of variations found over the gene or pathway...
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