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Article

Dynamic regulation of platelet-derived growth factor receptor α expression in alveolar fibroblasts during realveolarization.

American journal of respiratory cell and molecular biology - 1 Oct 2012

Chen Leiling, Acciani Thomas, Le Cras Tim, Lutzko Carolyn, Perl Anne-Karina T

Abstract excerpt

Although the importance of platelet-derived growth factor receptor (PDGFR)-α signaling during normal alveogenesis is known, it is unclear whether this signaling pathway can regulate realveolarization in the adult lung. During alveolar development, PDGFR-α-expressing cells induce α smooth muscle actin (α-SMA) and differentiate to interstitial myofibroblasts. Fibroblast growth factor (FGF) signaling regulates...

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Source

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Identifiers

PMID: 22652199
DOI: 10.1165/rcmb.2012-0030OC
PMCID: PMC3488620

Genes

FGFR2

Provenance

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