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Article

Skeletal muscle mitochondrial uncoupling in a murine cancer cachexia model

28 Jun 2013

Abstract excerpt

Approximately half of all cancer patients present with cachexia, a condition in which disease-associated metabolic changes lead to a severe loss of skeletal muscle mass. Working toward an integrated and mechanistic view of cancer cachexia, we investigated the hypothesis that cancer promotes mitochondrial uncoupling in skeletal muscle. We subjected mice to in vivo phosphorous-31 nuclear magnetic resonance (31P...

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Identifiers

PMID: 23817738
DOI: 10.3892/ijo.2013.1998

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