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Article

Neu1 deficiency and fibrotic lymph node microenvironment lead to imbalance in M1/M2 macrophage polarization.

Frontiers in immunology - 1 Jan 2024

Escalona Emilia, Olate-Briones Alexandra, Albornoz-Muñoz Sofía, Bonacic-Doric Enzo, Rodríguez-Arriaza Francisca, Herrada Andrés A, Escobedo Noelia

Abstract excerpt

Macrophages play a pivotal role in tissue homeostasis, pathogen defense, and inflammation resolution. M1 and M2 macrophage phenotypes represent two faces in a spectrum of responses to microenvironmental changes, crucial in both physiological and pathological conditions. Neuraminidase 1 (Neu1), a lysosomal and cell surface sialidase responsible for removing terminal sialic acid residues from glycoconjugates,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39346907
DOI: 10.3389/fimmu.2024.1462853
PMCID: PMC11427323

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