Article
Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence.
Molecular psychiatry - 1 Aug 2021
Meng Weida, Sjöholm Louise K, Kononenko Olga, Tay Nicole, Zhang Dandan, Sarkisyan Daniil, Geske Jennifer R, Ing Alex, Qiu Wenqing, Watanabe Hiroyuki, Almamoun Radwa, Frieling Helge, Bleich Stefan, Cui Donghong, Biernacka Joanna M, Mayfield R Dayne, Dang Yongjun, Karpyak Victor M, Schumann Gunter, Bakalkin Georgy, Ekström Tomas J, Rüegg Joelle, Liu Yun
Abstract excerpt
Alcohol misuse is a major public health problem originating from genetic and environmental risk factors. Alterations in the brain epigenome may orchestrate changes in gene expression that lead to alcohol misuse and dependence. Through epigenome-wide association analysis of DNA methylation from human brain tissues, we identified a differentially methylated region, DMR-DLGAP2, associated with alcohol dependence....
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