Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mouse model of PRSS1 p.R122H-related hereditary pancreatitis highlights context-dependent effect of autolysis-site mutation.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Mar 2023

Jancsó Zsanett, Morales Granda Nataly C, Demcsák Alexandra, Sahin-Tóth Miklós

Abstract excerpt

Mutation p.R122H in human cationic trypsinogen (PRSS1) is the most frequently identified cause of hereditary pancreatitis. The mutation blocks protective degradation of trypsinogen by chymotrypsin C (CTRC), which involves an obligatory trypsin-mediated cleavage at Arg122. Previously, we found that C57BL/6N mice are naturally deficient in CTRC, and trypsinogen degradation is catalyzed by chymotrypsin B1 (CTRB1)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chymotrypsin
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mutation

Share to Pancreatitis

Share to Pancreatitis, Chronic

Share to Trypsin

Share to Trypsinogen

Source

Open in PubMed Open full text

Identifiers

PMID: 36797199
DOI: 10.1016/j.pan.2023.02.003
PMCID: PMC10492521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mouse model of PRSS1 p.R122H-related hereditary pancreatitis highlights context-dependent effect of autolysis-site mutation.PMID 36797199Read ↗

Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122HSemantic proximity Read ↗

A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen.Semantic proximity Read ↗

Evolutionary expansion of polyaspartate motif in the activation peptide of mouse cationic trypsinogen limits autoactivation and protects against pancreatitis.Semantic proximity Read ↗

Mutation That Promotes Activation of Trypsinogen Increases Severity of Secretagogue-Induced Pancreatitis in Mice.Semantic proximity Read ↗

Heterozygous Spink1 Deficiency Promotes Trypsin-dependent Chronic Pancreatitis in Mice.Semantic proximity Read ↗

Mouse model suggests limited role for human mesotrypsin in pancreatitis.Semantic proximity Read ↗

[Hereditary pancreatitis].Semantic proximity Read ↗

Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen.Semantic proximity Read ↗

Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop.Semantic proximity Read ↗

Hereditary pancreatitisSemantic proximity Read ↗

Hereditary pancreatitis: a model for understanding the genetic basis of acute and chronic pancreatitis.Semantic proximity Read ↗

Genetic background of pancreatitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.