Article
H-ras inhibits RhoA/ROCK leading to a decrease in the basal tone in the internal anal sphincter.
Gastroenterology - 1 Apr 2007
de Godoy Márcio A F, Patel Chirag A, Waldman Scott A, Katsuki Motoya, Regan Raymond F, Rattan Satish
Abstract excerpt
BACKGROUND & AIMS: The present studies evaluated the role of H-ras and its implications in the RhoA/Rho kinase (ROCK) pathway in regulating basal tone in the internal anal sphincter (IAS). METHODS: Studies were performed in the IAS from the wild-type (H-ras(+/+)) and knock-out (H-ras(-/-)) mice....
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