Article
Chaperonin overexpression promotes genetic variation and enzyme evolution.
Nature - 4 Jun 2009
Tokuriki Nobuhiko, Tawfik Dan S
Abstract excerpt
Most protein mutations, and mutations that alter protein functions in particular, undermine stability and are therefore deleterious. Chaperones, or heat-shock proteins, are often implicated in buffering mutations, and could thus facilitate the acquisition of neutral genetic diversity and the rate of adaptation. We examined the ability of the Escherichia coli GroEL/GroES chaperonins to buffer destabilizing and...
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