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Article

Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance.

British journal of cancer - 9 Aug 2011

Jeyapalan J N, Noor D A Mohamed, Lee S-H, Tan C L, Appleby V A, Kilday J P, Palmer R D, Schwalbe E C, Clifford S C, Walker D A, Murray M J, Coleman N, Nicholson J C, Scotting P J

Abstract excerpt

BACKGROUND: Yolk sac tumours (YSTs) and germinomas are the two major pure histological subtypes of germ cell tumours. To date, the role of DNA methylation in the aetiology of this class of tumour has only been analysed in adult testicular forms and with respect to only a few genes. METHODS: A bank of paediatric tumours was analysed for global methylation of LINE-1 repeat elements and global methylation of...

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Identifiers

PMID: 21712824
DOI: 10.1038/bjc.2011.218
PMCID: PMC3170957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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