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Article

Mitochondrial DNA homeostasis is essential for nigrostriatal integrity

12 Mar 2016

Abstract excerpt

Mitochondrial involvement in the pathogenesis of Parkinson's disease has been suggested by multiple studies, but the mechanisms involved remain unresolved. Here, we sought to identify which mitochondrial defects are associated with degeneration of the nigrostriatal system. Nigrostriatal integrity was assessed in vivo by dopamine transporter (DAT) imaging in twenty-one patients with mitochondrial disorders of...

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Identifiers

PMID: 26979109
DOI: 10.1016/j.mito.2016.03.003

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