Mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson's Disease Research Group.

doi:10.1002/ana.410320720

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Article

Mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson's Disease Research Group.

Annals of neurology - 1 Jan 1992

Schapira A H, Mann V M, Cooper J M, Krige D, Jenner P J, Marsden C D

Abstract excerpt

There is increasing evidence for a defect of mitochondrial respiratory chain function in Parkinson's disease. Specific NADH CoQ1 reductase (complex I) deficiency has been identified in the substantia nigra. Available evidence suggests that this defect is confined to the substantia nigra and is no...

Topics

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Cell Death
DNA, Mitochondrial
Electron Transport
Humans
Mitochondria
Mutation
NAD(P)H Dehydrogenase (Quinone)
Parkinson Disease
Substantia Nigra

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