Article
Mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson's Disease Research Group.
Annals of neurology - 1 Jan 1992
Schapira A H, Mann V M, Cooper J M, Krige D, Jenner P J, Marsden C D
Abstract excerpt
There is increasing evidence for a defect of mitochondrial respiratory chain function in Parkinson's disease. Specific NADH CoQ1 reductase (complex I) deficiency has been identified in the substantia nigra. Available evidence suggests that this defect is confined to the substantia nigra and is not present elsewhere in the parkinsonian brain. The absence of a detectable mitochondrial abnormality in the substantia...
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