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Article

Mitochondrial dysfunction in parkinson's disease

1 Sept 1998

Abstract excerpt

This review discusses the etiology and pathogenesis of Parkinson's disease (PD). Mitochondrial respiratory failure and oxidative stress appear to be two major contributors to nigral neuronal death in PD. Complex I deficiency has been reported by several groups and appears to be one of the basic abnormalities responsible for mitochondrial failure. The principal question is whether or not complex I deficiency is...

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Identifiers

PMID: 9749580
DOI: 10.1002/ana.410440715

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