Sex Difference in Effect of the OPRM1 Gene A118G (rs1799971) Single-Nucleotide Polymorphism on the Requirement for Postoperative Fentanyl in Japanese Patients Who Underwent Laparoscopic-Assisted Colectomy.

doi:10.1002/npr2.70140

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Sex Difference in Effect of the OPRM1 Gene A118G (rs1799971) Single-Nucleotide Polymorphism on the Requirement for Postoperative Fentanyl in Japanese Patients Who Underwent Laparoscopic-Assisted Colectomy.

Neuropsychopharmacology reports - 1 Jun 2026

Nakagawa Hideyuki, Nishizawa Daisuke, Mieda Tsutomu, Tsujita Miki, Kasai Shinya, Hasegawa Junko, Nakayama Kyoko, Ebata Yuko, Kitamura Akira, Hayashida Masakazu, Ikeda Kazutaka

Abstract excerpt

BACKGROUND: The A118G (rs1799971) single-nucleotide polymorphism (SNP) of the OPRM1 gene, which encodes the μ-opioid receptor, reportedly affects postoperative morphine requirements but not fentanyl requirements. The present study investigated whether this SNP influences postoperative fentanyl requirements after laparoscopic-assisted colectomy (LAC). METHODS: We examined 350 Japanese patients who underwent LAC...

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PMID: 42237480
DOI: 10.1002/npr2.70140

Genes

OPRM1

Variants

rs1799971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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