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Article

Effects of the gout-causing Q141K polymorphism and a CFTR ΔF508 mimicking mutation on the processing and stability of the ABCG2 protein.

Biochemical and biophysical research communications - 19 Jul 2013

Sarankó Hajnalka, Tordai Hedvig, Telbisz Ágnes, Özvegy-Laczka Csilla, Erdős Gábor, Sarkadi Balázs, Hegedűs Tamás

Abstract excerpt

ABCG2 is an important multidrug transporter involved also in urate transport, thus its mutations can lead to the development of gout and may also alter general drug absorption, distribution and excretion. The frequent ABCG2 polymorphism, Q141K, is associated with an elevated risk of gout and has...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phenylbutyrates

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Source

Identifiers

PMID: 23800412
DOI: 10.1016/j.bbrc.2013.06.054

Genes

ABCG2
CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23800412-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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