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Article

Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA

24 Jun 2013

Abstract excerpt

BACKGROUND: The K65R substitution in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is the major resistance mutation selected in patients treated with first-line antiretroviral tenofovir disoproxil fumarate (TDF). 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA), is the most potent nucleoside analog RT inhibitor (NRTI) that unlike all approved NRTIs retains a 3'-hydroxyl group and has...

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PMID: 23800377
DOI: 10.1186/1742-4690-10-65

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