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Article

Antiretroviral potency of 4'-ethnyl-2'-fluoro-2'-deoxyadenosine, tenofovir alafenamide and second-generation NNRTIs across diverse HIV-1 subtypes.

The Journal of antimicrobial chemotherapy - 1 Oct 2018

Njenda Duncan T, Aralaguppe Shambhu G, Singh Kamalendra, Rao Rohit, Sönnerborg Anders, Sarafianos Stefan G, Neogi Ujjwal

Abstract excerpt

Objectives: 4'-Ethnyl-2'-fluoro-2'-deoxyadenosine (EFdA) is a novel translocation-defective reverse transcriptase inhibitor. We investigated the virological and biochemical inhibitory potentials of EFdA against a broad spectrum of subtype-specific chimeric viruses and compared it with tenofovir alafenamide, nevirapine, efavirenz, rilpivirine and etravirine. Methods: pNL4.3 chimeric viruses encoding gag-pol from...

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Identifiers

PMID: 30053052
DOI: 10.1093/jac/dky256
PMCID: PMC6148215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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