Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

doi:10.1101/gad.4.5.683

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Article

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

Genes & development - 1 May 1990

Martin-Zanca D, Barbacid M, Parada L F

Abstract excerpt

We have cloned and characterized the mouse homolog of the human trk proto-oncogene, a member of the protein tyrosine kinase (TK) receptor gene family. Here, we present the first report of a trk-encoded mRNA species in vivo. In situ hybridization analysis in the mouse embryo reveals a striking temporal and spatial regulation of trk transcription, with expression confined to the sensory cranial (trigeminal,...

Topics

Animals
Blotting, Northern
Cloning, Molecular
Ganglia
Ganglia, Spinal
Gene Expression Regulation, Neoplastic
Humans
Mice
Multigene Family
Mutation
Neural Crest

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein-Tyrosine Kinases

Proto-Oncogene Mas

Proto-Oncogenes

RNA, Messenger

Restriction Mapping

Sequence Homology, Nucleic Acid

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 2379826
DOI: 10.1101/gad.4.5.683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2379826-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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