Biotinylated oligonucleotide probes for the detection and the characterization of TEM-type extended broad spectrum beta-lactamases in Enterobacteriaceae.

doi:10.1016/0378-1097(90)90423-n

Back to search

Article

Biotinylated oligonucleotide probes for the detection and the characterization of TEM-type extended broad spectrum beta-lactamases in Enterobacteriaceae.

FEMS microbiology letters - 1 May 1990

Tham T N, Mabilat C, Courvalin P, Guesdon J L

Abstract excerpt

Point mutations in the nucleotide sequence of the structural genes for the TEM-type penicillinases can broaded their substrate spectrum towards all beta-lactams except cephamycins and imipenem. The presence of such variants on self-transferable plasmids accounts for the dissemination of this new...

Topics

Base Sequence
Enterobacteriaceae
Genes, Bacterial
Molecular Sequence Data
Mutation
Oligonucleotide Probes
beta-Lactamases

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.