Article
Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR.
Nature - 29 Jul 2004
Korzhnev Dmitry M, Salvatella Xavier, Vendruscolo Michele, Di Nardo Ariel A, Davidson Alan R, Dobson Christopher M, Kay Lewis E
Abstract excerpt
Many biochemical processes proceed through the formation of functionally significant intermediates. Although the identification and characterization of such species can provide vital clues about the mechanisms of the reactions involved, it is challenging to obtain information of this type in cases where the intermediates are transient or present only at low population. One important example of such a situation...
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