Article
High populations of non-native structures in the denatured state are compatible with the formation of the native folded state.
Journal of molecular biology - 11 Dec 1998
Blanco F J, Serrano L, Forman-Kay J D
Abstract excerpt
The structures of the denatured states of the spectrin SH3 domain and a mutant designed to have a non-native helical tendency at the N terminus have been analyzed under mild acidic denaturing conditions by nuclear magnetic resonance methods with improved resolution. The wild-type denatured state...
Topics
- Amino Acid Sequence
- Drug Stability
- Magnetic Resonance Spectroscopy
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Protein Conformation
- Protein Denaturation
- Protein Folding
- Protein Structure, Secondary
- Spectrin
- src Homology Domains