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Article

Stiffness of the distal loop restricts the structural heterogeneity of the transition state ensemble in SH3 domains.

Journal of molecular biology - 12 Apr 2002

Klimov D K, Thirumalai D

Abstract excerpt

Protein engineering experiments and Phi(F)-value analysis of SH3 domains reveal that their transition state ensemble (TSE) is conformationally restricted, i.e. the fluctuations in the transition state (TS) structures are small. In the TS of src SH3 and alpha-spectrin SH3 the distal loop and the associated hairpin are fully structured, while the rest of the protein is relatively disordered. If native structure...

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Identifiers

PMID: 11955020
DOI: 10.1006/jmbi.2002.5453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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