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Article

Similarities between the spectrin SH3 domain denatured state and its folding transition state.

Journal of molecular biology - 14 Apr 2000

Kortemme T, Kelly M J, Kay L E, Forman-Kay J, Serrano L

Abstract excerpt

We have expanded our description of the energy landscape for folding of the SH3 domain of chicken alpha-spectrin by a detailed structural characterization of its denatured state ensemble (DSE). This DSE is significantly populated under mildly acidic conditions in equilibrium with the folded state...

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Source

Identifiers

PMID: 10764585
DOI: 10.1006/jmbi.2000.3618

Genes

DSE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10764585-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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