Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of defective complement control in hemolytic uremic syndrome.

Seminars in thrombosis and hemostasis - 1 Mar 2006

Zipfel Peter F, Misselwitz Joachim, Licht Christoph, Skerka Christine

Abstract excerpt

Atypical hemolytic uremic syndrome (HUS) is a severe disease that is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Recent evidence has shown that defective complement activation and defective complement control is a cause of HUS. So far, mutations in single genes coding for the cofactor and complement regulator factor H, the membrane cofactor protein (MCP/CD46),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement Factor H
Share to Complement Pathway, Alternative

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement System Proteins

Share to Fibrinogen

Share to Hemolytic-Uremic Syndrome

Share to Membrane Cofactor Protein

Share to Models, Biological

Share to Mutation

Source

Identifiers

PMID: 16575689
DOI: 10.1055/s-2006-939770

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of defective complement control in hemolytic uremic syndrome.PMID 16575689Read ↗

Complement dysfunction in hemolytic uremic syndrome.Semantic proximity Read ↗

Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome.Semantic proximity Read ↗

Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome.Semantic proximity Read ↗

Atypical hemolytic uremic syndrome: update on the complement system and what is new.Semantic proximity Read ↗

Atypical hemolytic uremic syndrome: genetically-based insights into pathogenesis through an analysis of the complement regulator CD46Semantic proximity Read ↗

Hemolytic Uremic Syndrome: An Example of Insufficient Complement Regulation on Self‐TissueSemantic proximity Read ↗

Atypical haemolytic uraemic syndrome.Semantic proximity Read ↗

Alternative complement pathway assessment in patients with atypical HUS.Semantic proximity Read ↗

Complement regulator CD46: genetic variants and disease associations.Semantic proximity Read ↗

Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome.Semantic proximity Read ↗

Complement regulatory genes and hemolytic uremic syndromes.Semantic proximity Read ↗

Genetics and complement in atypical HUS.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.