Article
Serological and genetic complement alterations in infection-induced and complement-mediated hemolytic uremic syndrome.
Pediatric nephrology (Berlin, Germany) - 1 Feb 2017
Westra Dineke, Volokhina Elena B, van der Molen Renate G, van der Velden Thea J A M, Jeronimus-Klaasen Annelies, Goertz Joop, Gracchi Valentina, Dorresteijn Eiske M, Bouts Antonia H M, Keijzer-Veen Mandy G, van Wijk Joanna A E, Bakker Jaap A, Roos Anja, van den Heuvel Lambert P, van de Kar Nicole C A J
Abstract excerpt
BACKGROUND: The role of complement in the atypical form of hemolytic uremic syndrome (aHUS) has been investigated extensively in recent years. As the HUS-associated bacteria Shiga-toxin-producing Escherichia coli (STEC) can evade the complement system, we hypothesized that complement dysregulation is also important in infection-induced HUS. METHODS: Serological profiles (C3, FH, FI, AP activity, C3d, C3bBbP,...
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