ID1‐, ID2‐, and ID3‐regulated gene expression in E2A positive or negative prostate cancer cells

Abstract excerpt

BACKGROUND: The inhibitor of differentiation (Id) proteins are expressed in prostate cancer (PCA). However, there is a general lack of Id isoform-specific downstream effectors. METHODS: Id1, Id2, or Id3 were silenced in PCA cell lines LNCaP, DU145, and PC3 using gene-specific small interfering RNA (siRNA). The effect of Id gene silencing on representative genes involved in apoptosis (p53, SNAIL2), proliferation...

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