Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear lamina structure and meiotic chromosome segregation have different requirements for dTopors-mediated ubiquitination in male Drosophila melanogaster.

Genetics - 10 Dec 2025

Binder Andrea M, Shore Charlotte D, Stanisławczyk Lena S, Tomkiel Dean John E

Abstract excerpt

In Drosophila melanogaster, the dual E3 Ubiquitin/SUMO-1 ligase dTopors localizes to the spermatocyte nuclear lamina and is required for nuclear morphology and meiotic chromosome transmission. To investigate the role of dTopors-mediated ubiquitination, we use CRISPR/Cas9 to mutate the ubiquitination domain. Two mutants were recovered: C105A, a substitution of a conserved cysteine, and Df(114-118), a hypomorphic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Segregation
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Meiosis

Share to Nuclear Lamina

Share to Spermatocytes

Share to Ubiquitin-Conjugating Enzymes

Share to Ubiquitin-Protein Ligases

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 41100696
DOI: 10.1093/genetics/iyaf223
PMCID: PMC13376422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear lamina structure and meiotic chromosome segregation have different requirements for dTopors-mediated ubiquitination in male Drosophila melanogaster.PMID 41100696Read ↗

Nuclear structure and chromosome segregation in Drosophila male meiosis depend on the ubiquitin ligase dTopors.Semantic proximity Read ↗

Wdr62 and Patronin cooperate to organize distinct acentrosomal microtubule networks during <i>Drosophila</i> oogenesisSemantic proximity Read ↗

Centromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligases.Semantic proximity Read ↗

The Drosophila UBC9 homologue lesswright mediates the disjunction of homologues in meiosis I.Semantic proximity Read ↗

Mitotic Nuclear Envelope Breakdown and Spindle Nucleation Are Controlled by Interphase Contacts between Centromeres and the Nuclear Envelope.Semantic proximity Read ↗

Condensin II resolves chromosomal associations to enable anaphase I segregation in Drosophila male meiosis.Semantic proximity Read ↗

Active maintenance of meiosis-specific chromosome structures in Caenorhabditis elegans by the deubiquitinase DUO-1.Semantic proximity Read ↗

The male germline-specific protein MAPS is indispensable for pachynema progression and fertilitySemantic proximity Read ↗

E3 Ubiquitin Ligase TRIM Proteins, Cell Cycle and MitosisSemantic proximity Read ↗

High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I.Semantic proximity Read ↗

Chemogenetic profiling of ubiquitin-like modifier pathways identifies NFATC2IP as a mediator of SUMO-dependent genome integritySemantic proximity Read ↗

The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.