Article
Systemic down-regulation of delta-9 desaturase promotes muscle oxidative metabolism and accelerates muscle function recovery following nerve injury.
PloS one - 1 Jan 2013
Hussain Ghulam, Schmitt Florent, Henriques Alexandre, Lequeu Thiebault, Rene Frederique, Bindler Françoise, Dirrig-Grosch Sylvie, Oudart Hugues, Palamiuc Lavinia, Metz-Boutigue Marie-Helene, Dupuis Luc, Marchioni Eric, Gonzalez De Aguilar Jose-Luis, Loeffler Jean-Philippe
Abstract excerpt
The progressive deterioration of the neuromuscular axis is typically observed in degenerative conditions of the lower motor neurons, such as amyotrophic lateral sclerosis (ALS). Neurodegeneration in this disease is associated with systemic metabolic perturbations, including hypermetabolism and dyslipidemia. Our previous gene profiling studies on ALS muscle revealed down-regulation of delta-9 desaturase, or SCD1,...
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