Article

Inhibiting 5-lipoxygenase prevents skeletal muscle atrophy by targeting organogenesis signaling and insulin-like growth factor-1

2022-05-04

Abstract excerpt

<h4>Background</h4> Skeletal muscle atrophy can occur in response to numerous factors, such as aging and certain medications, and produces a major socioeconomic burden. At present, there are no approved drugs for treating skeletal muscle atrophy. Arachidonate 5-lipoxygenase (Aox5) is a drug target for a number of diseases. However, pharmacological targeting of Alox5, and its role in skeletal muscle atrophy, is un...

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Literature Corpus work: 3ac8d6e4-8b66-5911-96b9-6eeac6e75946
DOI: 10.1101/2022.05.04.490621

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