Article

Neuronal polyunsaturated fatty acids are protective in FTD/ALS

2024-01-17

Abstract excerpt

We report a conserved transcriptomic signature of reduced fatty acid and lipid metabolism gene expression in human post-mortem ALS spinal cord and a Drosophila model of the most common genetic cause of FTD/ALS, a repeat expansion in C9orf72 . To investigate lipid alterations, we performed lipidomics on C9FTD/ALS iPSC-neurons and post-mortem FTLD brain tissue. This revealed a common and specific reduction in phos...

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Literature Corpus work: 610455ff-1e51-5167-8398-5da2f7339ab8
DOI: 10.1101/2024.01.16.575677

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