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Article

Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS.

Communications biology - 30 Apr 2021

Trabjerg Michael Sloth, Andersen Dennis Christian, Huntjens Pam, Oklinski Kirsten Egelund, Bolther Luise, Hald Jonas Laugård, Baisgaard Amalie Elton, Mørk Kasper, Warming Nikolaj, Kullab Ulla Bismark, Kroese Lona John, Pritchard Colin Eliot Jason, Huijbers Ivo Johan, Nieland John Dirk Vestergaard

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease characterized by death of motor neurons. The etiology and pathogenesis remains elusive despite decades of intensive research. Herein, we report that dysregulated metabolism plays a central role in the SOD1 G93A mouse model mimicking ALS. Specifically, we report that the activity of carnitine palmitoyl transferase 1 (CPT1) lipid metabolism is...

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Identifiers

PMID: 33931719
DOI: 10.1038/s42003-021-02034-z
PMCID: PMC8087699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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