Infiltration by CXCL10 Secreting Macrophages Is Associated With Antitumor Immunity and Response to Therapy in Ovarian Cancer Subtypes.

doi:10.3389/fimmu.2021.690201

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Article

Infiltration by CXCL10 Secreting Macrophages Is Associated With Antitumor Immunity and Response to Therapy in Ovarian Cancer Subtypes.

Frontiers in immunology - 1 Jan 2021

Ardighieri Laura, Missale Francesco, Bugatti Mattia, Gatta Luisa Benerini, Pezzali Irene, Monti Matilde, Gottardi Stefano, Zanotti Laura, Bignotti Eliana, Ravaggi Antonella, Tognon Germana, Odicino Franco, Calza Stefano, Missolo-Koussou Yoann, Ries Carola Hermine, Helft Julie, Vermi William

Abstract excerpt

Ovarian carcinomas (OCs) are poorly immunogenic and immune checkpoint inhibitors (ICIs) have offered a modest benefit. In this study, high CD3+ T-cells and CD163+ tumor-associated macrophages (TAMs) densities identify a subgroup of immune infiltrated high-grade serous carcinomas (HGSCs) with better outcomes and superior response to platinum-based therapies. On the contrary, in most clear cell carcinomas (CCCs)...

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Identifiers

PMID: 34220848
DOI: 10.3389/fimmu.2021.690201
PMCID: PMC8253056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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