Linkage analysis of quantitative traits: increased power by using selected samples.

Article

Linkage analysis of quantitative traits: increased power by using selected samples.

American journal of human genetics - 1 Oct 1991

Carey G, Williamson J

Abstract excerpt

Although a number of methods have been developed for linkage analysis of quantitative traits, power is relatively poor unless there is a single major locus of very large effect. Here it is demonstrated that the use of selected samples (i.e., ascertainment of a proband with an extreme score on the...

Topics

Gene Frequency
Genes, Recessive
Genetic Linkage
Genetic Variation
Genotype
Humans
Mathematics
Models, Statistical
Phenotype
Regression Analysis
Sampling Studies

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