Article
Do CDKN2 p16 540 C>G, CDKN2 p16 580 C>T, and MDM2 SNP309 T>G gene variants act on colorectal cancer development or progression?
DNA and cell biology - 1 Jul 2013
Tuna Gülay, Küçükhüseyin Ozlem, Arıkan Soykan, Kaytan Sağlam Esra, Güler Erkan, Cacına Canan, Oztop Ozge, Turan Saime, Korkmaz Gurbet, Yaylım Ilhan
Abstract excerpt
CDNK2 p16 plays a pivotal role in G1/S transition by regulating the p53 pathway, which was regulated by a nuclear oncoprotein, mouse double minute 2 (MDM2). Overexpression of the MDM2 gene has been shown in a number of tumor types, its gene amplification is found to associate with accelerated tumor development and failure to treatment in both hereditary and sporadic cancers. Although genetic association studies...
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