Article
Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy.
Breast cancer research : BCR - 1 Jan 2008
Fillmore Christine M, Kuperwasser Charlotte
Abstract excerpt
INTRODUCTION: The phenotypic and functional differences between cells that initiate human breast tumors (cancer stem cells) and those that comprise the tumor bulk are difficult to study using only primary tumor tissue. We embarked on this study hypothesizing that breast cancer cell lines would contain analogous hierarchical differentiation programs to those found in primary breast tumors. METHODS: Eight human...
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