Article
Evidence that the conserved region in the steroid binding domain of the glucocorticoid receptor is required for both optimal binding of hsp90 and protection from proteolytic cleavage. A two-site model for hsp90 binding to the steroid binding domain.
The Journal of biological chemistry - 5 Aug 1990
Housley P R, Sanchez E R, Danielsen M, Ringold G M, Pratt W B
Abstract excerpt
Steroid hormone receptors contain a conserved sequence of amino acids within the steroid binding domain, and we have previously speculated that this conserved region is the site of interaction of the glucocorticoid receptor with hsp90 (Danielsen, M., Northrop, J. P., and Ringold, G. M. (1986) EMBO J. 5, 2513-2522; Pratt, W. B., Jolly, D. J., Pratt, D. V., Hollenberg, S. M., Giguere, V., Cadepond, F. M.,...
Topics
- Animals
- Binding Sites
- Blotting, Western
- Cell Line
- Cytosol
- Heat-Shock Proteins
- Mice
- Models, Biological
- Molecular Weight
- Molybdenum