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Article

Mapping the HSP90 binding region of the glucocorticoid receptor.

The Journal of biological chemistry - 15 Jul 1990

Howard K J, Holley S J, Yamamoto K R, Distelhorst C W

Abstract excerpt

In animal cells, unliganded steroid receptors are complexed with a 90-kDa heat shock protein, HSP90; hormone binding by the receptor leads to the release of HSP90. We found that the 795-amino acid rat glucocorticoid receptor protein formed oligomeric complexes in vitro upon synthesis in rabbit reticulocyte lysates; these oligomers also dissociated in the presence of hormone. Similar complexes formed when X795, a...

Topics

Animals
Antibodies, Monoclonal
Binding Sites
Cell Line
Chromatography, Gel
Chromosome Deletion
Heat-Shock Proteins
Mutation
Plasmids
Protein Binding
Protein Biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Receptors, Glucocorticoid

Reticulocytes

Transcription, Genetic

Source

Identifiers

PMID: 2365707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2365707-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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