Article
Comparison of the 90-kilodalton heat shock protein interaction with in vitro translated glucocorticoid and estrogen receptors.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1992
Schlatter L K, Howard K J, Parker M G, Distelhorst C W
Abstract excerpt
The rat glucocorticoid receptor is a 795-amino acid protein with the hormone binding domain located in the C-terminal portion of the molecule. In the absence of hormone, this domain displays a protein inactivation activity that represses the nuclear localization, DNA binding, and transcriptional regulatory activities of the receptor. This inactivation activity, which appears to be mediated by the 90-kilodalton...
Topics
- Animals
- Heat-Shock Proteins
- In Vitro Techniques
- Mutation
- Precipitin Tests
- Protein Biosynthesis
- Rats
- Receptors, Estrogen
- Receptors, Glucocorticoid