Article
Prognostic impact of a single-nucleotide polymorphism near the CTSO gene in hormone receptor-positive breast cancer patients.
International journal of clinical oncology - 1 Jun 2016
Hato Yukari, Kondo Naoto, Yoshimoto Nobuyasu, Endo Yumi, Asano Tomoko, Dong Yu, Nishimoto Mayumi, Takahashi Satoru, Fujii Yoshitaka, Nakanishi Ryoichi, Toyama Tatsuya
Abstract excerpt
BACKGROUND: Tamoxifen can reduce the occurrence of breast cancer by a half in high-risk women. Recently, a genome-wide association study identified two single-nucleotide polymorphisms (SNPs) near or in the CTSO and ZNF423 genes that were associated with breast cancer risk during tamoxifen therapy. We hypothesized that these two SNPs could be associated with increased recurrence in breast cancer patients who...
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