Article
Two distinct mechanisms underlie estrogen-receptor-negative breast cancer susceptibility at the 2p23.2 locus.
European journal of human genetics : EJHG - 1 Apr 2022
Mendoza-Fandiño Gustavo, Lyra Paulo Cilas M, Nepomuceno Thales C, Harro Carly M, Woods Nicholas T, Li Xueli, Rangel Leticia B, Carvalho Marcelo A, Couch Fergus J, Monteiro Alvaro N A
Abstract excerpt
Genome wide-association studies (GWAS) have established over 400 breast cancer risk loci defined by common single nucleotide polymorphisms (SNPs), including several associated with estrogen-receptor (ER)-negative disease. Most of these loci have not been studied systematically and the mechanistic underpinnings of risk are largely unknown. Here we explored the landscape of genomic features at an ER-negative breast...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.