Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ERα-positive breast cancer through regulation of BRCA1.

PLoS genetics - 1 Oct 2017

Cairns Junmei, Ingle James N, Wickerham Lawrence D, Weinshilboum Richard, Liu Mohan, Wang Liewei

Abstract excerpt

Tamoxifen is one of the most commonly employed endocrine therapies for patients with estrogen receptor α (ERα)-positive breast cancer. Unfortunately the clinical benefit is limited due to intrinsic and acquired drug resistance. We previously reported a genome-wide association study that identified common SNPs near the CTSO gene and in ZNF423 associated with development of breast cancer during tamoxifen therapy in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to Cathepsins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Drug Resistance, Neoplasm

Share to Estrogen Receptor alpha

Share to Gene Expression Regulation, Neoplastic

Share to Proteins

Share to Tamoxifen

Source

Open in PubMed Open full text

Identifiers

PMID: 28968398
DOI: 10.1371/journal.pgen.1007031
PMCID: PMC5638617

Genes

CTSO
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ERα-positive breast cancer through regulation of BRCA1.PMID 28968398Read ↗

Prognostic impact of a single-nucleotide polymorphism near the CTSO gene in hormone receptor-positive breast cancer patients.Semantic proximity Read ↗

Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression: individualized breast cancer prevention.Semantic proximity Read ↗

Relationship of ZNF423 and CTSO with breast cancer risk in two randomised tamoxifen prevention trials.Semantic proximity Read ↗

Cysteine cathepsins: From diagnosis to targeted therapy of cancerSemantic proximity Read ↗

Discovery of a Novel Class of PROTACs as Potent and Selective Estrogen Receptor α Degraders to Overcome Endocrine-Resistant Breast Cancer In Vitro and In VivoSemantic proximity Read ↗

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast CancerSemantic proximity Read ↗

Cathepsins and cancer risk: a Mendelian randomization study.Semantic proximity Read ↗

Interplay of ERα binding and DNA methylation in the intron-2 determines the expression and estrogen regulation of Cystatin A in breast cancer cellsSemantic proximity Read ↗

Repression of cathepsin E expression increases the risk of mammary carcinogenesis and links to poor prognosis in breast cancer.Semantic proximity Read ↗

Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion.Semantic proximity Read ↗

Prolylcarboxypeptidase Promotes IGF1R/HER3 Signaling and Is a Potential Target to Improve Endocrine Therapy Response in Estrogen Receptor Positive Breast CancerSemantic proximity Read ↗

Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.