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Article

Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers.

Drug and alcohol dependence - 1 May 2013

Yang Zhongli, Seneviratne Chamindi, Wang Shaolin, Ma Jennie Z, Payne Thomas J, Wang Jundong, Li Ming D

Abstract excerpt

BACKGROUND: Pharmacologic studies implicate a significant role of genes encoding the serotonin transporter (SLC6A4) and the 5-HT3AB subunits HTR3A and HTR3B in nicotine dependence (ND). However, whether they are involved in ND remains largely unknown. METHODS: Here, we examined the impact of variations in the three genes on ND in 1366 individuals from 402 African American (AA) and 671 individuals from 200...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Receptors, Serotonin, 5-HT3

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Source

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Identifiers

PMID: 23290502
DOI: 10.1016/j.drugalcdep.2012.12.007
PMCID: PMC3628090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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