Article
Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers.
Drug and alcohol dependence - 1 May 2013
Yang Zhongli, Seneviratne Chamindi, Wang Shaolin, Ma Jennie Z, Payne Thomas J, Wang Jundong, Li Ming D
Abstract excerpt
BACKGROUND: Pharmacologic studies implicate a significant role of genes encoding the serotonin transporter (SLC6A4) and the 5-HT3AB subunits HTR3A and HTR3B in nicotine dependence (ND). However, whether they are involved in ND remains largely unknown. METHODS: Here, we examined the impact of variations in the three genes on ND in 1366 individuals from 402 African American (AA) and 671 individuals from 200...
Topics
- Adult
- Black or African American
- Epistasis, Genetic
- Female
- Humans
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Receptors, Serotonin, 5-HT3
- Serotonin Plasma Membrane Transport Proteins
- Tobacco Use Disorder
- White People