Article
HiSSI: high-order SNP-SNP interactions detection based on efficient significant pattern and differential evolution.
BMC medical genomics - 30 Dec 2019
Cao Xia, Liu Jie, Guo Maozu, Wang Jun
Abstract excerpt
BACKGROUND: Detecting single nucleotide polymorphism (SNP) interactions is an important and challenging task in genome-wide association studies (GWAS). Various efforts have been devoted to detect SNP interactions. However, the large volume of SNP datasets results in such a big number of high-order SNP combinations that restrict the power of detecting interactions. METHODS: In this paper, to combat with this...
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