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Inhibition of CEBPB Attenuates Lupus Nephritis via Regulating Pim-1 Signaling

20 Sept 2022

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disease leading to inflammatory damage in multiple target organs, and lupus nephritis (LN) is one of the most life-threatening organ manifestations. CCAAT/enhancer-binding protein β (CEBPB) regulates the NLRP3 inflammasome and is involved in the pathogenesis of SLE. However, the role and mechanism of CEBPB in LN remains unclear. MRL/lpr mice and...

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PMID: 36248187
DOI: 10.1155/2022/2298865

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