Article
Complex multi-block analysis identifies new immunologic and genetic disease progression patterns associated with the residual β-cell function 1 year after diagnosis of type 1 diabetes.
PloS one - 1 Jan 2013
Andersen Marie Louise Max, Rasmussen Morten Arendt, Pörksen Sven, Svensson Jannet, Vikre-Jørgensen Jennifer, Thomsen Jane, Hertel Niels Thomas, Johannesen Jesper, Pociot Flemming, Petersen Jacob Sten, Hansen Lars, Mortensen Henrik Bindesbøl, Nielsen Lotte Brøndum
Abstract excerpt
The purpose of the present study is to explore the progression of type 1 diabetes (T1D) in Danish children 12 months after diagnosis using Latent Factor Modelling. We include three data blocks of dynamic paraclinical biomarkers, baseline clinical characteristics and genetic profiles of diabetes related SNPs in the analyses. This method identified a model explaining 21.6% of the total variation in the data set....
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