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Article

Incomplete B cell tolerance to cartilage oligomeric matrix protein in mice.

Arthritis and rheumatism - 1 Sept 2013

Geng Hui, Nandakumar Kutty Selva, Xiong Li, Jie Rui, Dong Jiahui, Holmdahl Rikard

Abstract excerpt

OBJECTIVE: Cartilage oligomeric matrix protein (COMP) is a major noncollagenous component of cartilage and is used as a biomarker in rheumatoid arthritis and experimental arthritis. Injection of COMP leads to severe inflammatory joint disease, and antibodies play a critical role in mediating arthritis. The arthritogenicity of COMP might be due to the lack of self tolerance. This study was undertaken to determine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23754310
DOI: 10.1002/art.38046

Genes

COMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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