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Cartilage Oligomeric Matrix Protein-Deficient Mice Have Normal Skeletal Development

1 Jun 2002

Abstract excerpt

Cartilage oligomeric matrix protein (COMP) belongs to the thrombospondin family and is a homopentamer primarily expressed in cartilage. Mutations in the COMP gene result in the autosomal dominant chondrodysplasias pseudoachondroplasia (PSACH) and some types of multiple epiphyseal dysplasia (MED), which are characterized by mild to severe short-limb dwarfism and early-onset osteoarthritis. We have generated...

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Identifiers

PMID: 12024046
DOI: 10.1128/mcb.22.12.4366-4371.2002

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Cartilage Oligomeric Matrix Protein-Deficient Mice Have Normal Skeletal DevelopmentPMID 12024046Read ↗

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